1,2-Dimethyldiazene 1-oxide
[(E)-methyl-NNO-azoxy]methane
CAS: 25843-45-2
Molecular Formula: C2H6N2O
1,2-Dimethyldiazene 1-oxide - Names and Identifiers
| Name | [(E)-methyl-NNO-azoxy]methane |
| Synonyms | AOM ONN-Azoxydimethane Dimethyldiazene 1-oxide 1,2-Dimethyldiazene 1-oxide (Z)-1,2-diMethyldiazene oxide [(E)-methyl-NNO-azoxy]methane Diazene, dimethyl-,1-oxide (9CI) AZOXYMETHANE, PRACTICAL GRADE, 13.4M |
| CAS | 25843-45-2 |
| InChI | InChI=1/C2H6N2O/c1-3-4(2)5/h1-2H3/b4-3+ |
1,2-Dimethyldiazene 1-oxide - Physico-chemical Properties
| Molecular Formula | C2H6N2O |
| Molar Mass | 74.08 |
| Density | 0.991 g/mL at 25 °C (lit.) |
| Boling Point | 97-99 °C (lit.) |
| Flash Point | 24°C |
| Vapor Presure | 59.7mmHg at 25°C |
| Specific Gravity | 0.991 |
| Color | Oil |
| Storage Condition | -20°C |
| Refractive Index | 1.4368 (estimate) |
| In vitro study | Azoxymethane is a colon carcinogen which leads to the formation of DNA adducts. On an equal protein basis, hepatic microsomes are much more active than SI and colon microsomes in NADPH-dependent Azoxymethane bioactivation and N 7 -mG adduct formation. Hepatic microsomes show the highest activity in the hydroxylation of Azoxymethane, followed by SI and colon microsomes. |
| In vivo study | Regardless of the strain, the amounts of O 6 -mG and N 7 -mG produced by Azoxymethane are highest in the liver, followed by proximal and distal colons, which have similar levels, and then by duodenum, jejunum and ileum. Results indicate that the Azoxymethane-induced DNA adduct formation in the SI and colon does not depend on bioactivation by hepatic P450 enzymes. Irrespective of the mouse strain, no aberrant crypt foci (ACF) is detected in the colons of saline-treated mice; in contrast, colonic ACF is detected in all three strains of Azoxymethane-treated mice. The Azoxymethane-treated athymic mice have approximately an 11-fold lower tumor incidence than similarly treated WT animals. |
1,2-Dimethyldiazene 1-oxide - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | R45 - May cause cancer R46 - May cause heritable genetic damage R10 - Flammable R25 - Toxic if swallowed R34 - Causes burns R36/38 - Irritating to eyes and skin. |
| Safety Description | S53 - Avoid exposure - obtain special instructions before use. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 1992 3/PG 3 |
| WGK Germany | 3 |
| RTECS | PA2975000 |
| Toxicity | mma-sat 13,600 mmol/L/20M CNREA8 38,4585,78 |
1,2-Dimethyldiazene 1-oxide - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| biological activity | Azoxymethane is a colon carcinogen that can lead to the formation of DNA adduct. |
| category | toxic substances |
| toxicity classification | highly toxic |
| acute toxicity | subcutaneous-rat LD50: 27 mg/kg |
| flammability hazard characteristics | combustible; combustion produces toxic nitrogen oxide smoke |
| storage and transportation characteristics | ventilation and low temperature drying; separate from warehouse food raw materials |
| fire extinguishing agent | dry powder, foam, sand, carbon dioxide, mist water |
Last Update：2024-04-09 21:32:01
